SPRAVATO® Treatment for Depression

When Standard Treatments Haven't Been Enough

SPRAVATO® (esketamine) is an FDA-approved treatment for adults with treatment-resistant depression and certain severe depressive episodes. Offered in a calm, private clinical setting, SPRAVATO® provides a medically supervised option for individuals who continue to struggle despite traditional antidepressant therapy.

At Resolute, we combine advanced psychiatric care with a discreet, patient-centered experience — because hope should feel both accessible and dignified.

You Are Not Out of Options

If you've tried multiple antidepressants and still feel stuck, exhausted, or disconnected, SPRAVATO® may offer a new path forward.

Many patients pursue SPRAVATO® because they are:

• Tired of cycling through medications without meaningful relief
• Struggling with persistent depression despite therapy and medication
• Seeking a treatment that works differently than standard antidepressants

You are not failing treatment — the treatment may not have been right for you.

What Is SPRAVATO®?

SPRAVATO® is a prescription esketamine nasal spray, administered in-clinic under medical supervision and used alongside an oral antidepressant.

Unlike traditional antidepressants that target serotonin or norepinephrine, SPRAVATO® works through glutamate pathways, offering a distinct mechanism of action for depression that has not responded to standard care.

SPRAVATO® is not a take-home medication and is only available through certified healthcare providers.

What Does SPRAVATO® Treat?

SPRAVATO® is FDA-approved for adults with:

• Treatment-Resistant Depression (TRD)
  Depression that has not adequately improved after trying two or more antidepressants at appropriate doses and duration.
• Major Depressive Disorder with acute suicidal ideation or behavior
  Used in combination with an oral antidepressant as part of urgent psychiatric care.

Why Patients Choose SPRAVATO®

• FDA-approved for treatment-resistant depression
• Different mechanism than traditional antidepressants
• Administered in a controlled medical environment
• Structured treatment with close monitoring
• May provide symptom relief when other treatments have failed

Individual results vary, and our clinicians carefully assess whether this treatment aligns with your needs and medical history.

Am I a Candidate for SPRAVATO®?

You may qualify for SPRAVATO® if you:

• Are 18 years or older
• Have a diagnosis of Major Depressive Disorder
• Have tried two or more antidepressant medications without adequate improvement
• Continue to experience significant depressive symptoms
• Are able to attend in-clinic treatment sessions
• Are willing to take an oral antidepressant as part of treatment

SPRAVATO® may not be appropriate if you have:

• Uncontrolled high blood pressure
• Certain heart, blood vessel, or neurological conditions
• A history of aneurysm or vascular malformation
• Are pregnant or breastfeeding
• Certain active substance use concerns

If you're unsure whether you qualify, a consultation allows us to determine the safest and most appropriate next step.

What to Expect at Resolute

Step 1: Confidential Consultation

We review your symptoms, prior treatments, medical history, and insurance benefits to determine eligibility.

Step 2: In-Clinic Treatment

• Self-administration of SPRAVATO® under staff supervision
• Relaxation in a private treatment room
• Continuous monitoring of blood pressure and well-being
• Typical visit time: approximately two hours

Step 3: Ongoing Care

• A driver is required for discharge
• No driving until the next day
• Treatment frequency adjusted based on your response

Typical Treatment Schedule

Treatment is individualized, but many patients follow this structure:

• Weeks 1–4: Twice-weekly sessions
• Weeks 5–8: Weekly sessions
• Maintenance: Every 1–2 weeks, as clinically indicated

Your provider will tailor the plan based on effectiveness and tolerability.

Safety & Monitoring

SPRAVATO® is available only through a restricted safety program (REMS) due to the potential for sedation, dissociation, and temporary increases in blood pressure.

Common Temporary Side Effects May Include:

• Dizziness or lightheadedness
• Sedation or sleepiness
• Nausea
• Headache
• Dissociation or altered perception
• Temporary blood pressure elevation

All patients are monitored in-clinic to ensure safety prior to discharge.

Insurance & Payment

Many major insurance plans cover SPRAVATO® for qualifying patients, often with prior authorization.

Our team will assist with:

• Insurance verification
• Prior authorization support
• Clear explanation of expected costs

Coverage varies by plan.

Schedule Your SPRAVATO® Consultation

If depression has persisted despite your best efforts, SPRAVATO® may offer a new direction.

Resolute
319 Industrial Dr.
Longview, TX 75602
903-213-9120

Important Safety Information

SPRAVATO® may cause sedation, dissociation, and increases in blood pressure. Because of these risks, it must be administered in a certified healthcare setting with monitoring. Patients must not drive or operate machinery until the day after treatment following a full night's sleep. This content is for informational purposes only and does not replace professional medical advice. Treatment decisions are made by a licensed clinician.